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Literature summary for 2.3.1.48 extracted from

  • Sutton, A.; Shia, W.J.; Band, D.; Kaufman, P.D.; Osada, S.; Workman, J.L.; Sternglanz, R.
    Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex (2003), J. Biol. Chem., 278, 16887-16892.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Sas4 absolutely required for acetylation activity of Sas2 in SAS complex Saccharomyces cerevisiae
Sas5 stimulates acetylation activity of Sas2 in SAS complex Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli of SAS complex, consisting of Sas2, Sas4, and Sas5, Sas2 is His-tagged, coexpression Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
genes/proteins Sas2, Sas4, Sas5 forming the SAS complex
-

Purification (Commentary)

Purification (Comment) Organism
native SAS complex and recombinant SAS complex, the latter with Sas2 protein being His-tagged Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H3 recombinant and native SAS complex acetylates Lys14 Saccharomyces cerevisiae CoA + acetylhistone H3
-
?
acetyl-CoA + histone H4 SAS complex, native and recombinant, acetylates Lys16 Saccharomyces cerevisiae CoA + acetylhistone H4
-
?
additional information HeLa nucleosome or core histones are no substrate for recombinant SAS complex Saccharomyces cerevisiae ?
-
?
additional information for acetylation activity of Sas2, Sas4 is absolutely required, while Sas5 stimulate Saccharomyces cerevisiae ?
-
?

Synonyms

Synonyms Comment Organism
HAT
-
Saccharomyces cerevisiae