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Literature summary for 2.3.1.48 extracted from

  • Taipale, M.; Rea, S.; Richter, K.; Vilar, A.; Lichter, P.; Imhof, A.; Akhtar, A.
    hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells (2005), Mol. Cell. Biol., 25, 6798-6810.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone H4 Homo sapiens specific acetylation of Lys16, reversible acetylation of histones play an important role in regulation of chromatin structure and function. HMOF has a role in DNA damage responseduring cell cycle progression CoA + acetylhistone H4
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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 Homo sapiens
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Hep-G2 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H4 specific acetylation of Lys16, reversible acetylation of histones play an important role in regulation of chromatin structure and function. HMOF has a role in DNA damage responseduring cell cycle progression Homo sapiens CoA + acetylhistone H4
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 ?
acetyl-CoA + histone H4 specific acetylation of Lys16 Homo sapiens peptide CoA + acetylhistone H4 peptide
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 ?

Synonyms

Synonyms Comment Organism
hMOF
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 Homo sapiens