Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ethanol | ethanol induces the enzyme expression in the liver and activates the enzyme at specific lysine residues, e.g. Lys9 or Lys14, mechanisms of ethanol-induced histone H3 acetylation, overview | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
analysis and mechanism of gene expression | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Rattus norvegicus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 + acetyl-CoA | Rattus norvegicus | the enzyme is involved in ethanol-induced acetylation of histone H3 in hepatocytes, potential mechanism for gene expression activation by the enzyme, overview | acetyl-histone H3 + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | primary | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 + acetyl-CoA | the enzyme is involved in ethanol-induced acetylation of histone H3 in hepatocytes, potential mechanism for gene expression activation by the enzyme, overview | Rattus norvegicus | acetyl-histone H3 + CoA | - |
? | |
histone H3 + acetyl-CoA | acetylation at Lys9 and Lys14 | Rattus norvegicus | acetyl-histone H3 + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HAT | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Rattus norvegicus |