Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Lys-CoA | autoacetylation IC50: 100 nM, below | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics, site-specific kinetic analysis of loop autoacetylation, PCAF-mediated autoacetylation, overview | Homo sapiens | |
0.0033 | - |
acetyl-CoA | autoacetylation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone + acetyl-CoA | Homo sapiens | - |
acetyl-histone + CoA | - |
? | |
additional information | Homo sapiens | acetylation of proteins by the enzyme plays a critical role in the regulation of gene expression | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | p300 performs autoacetylation e.g. at Lys1555, Lys1554, Lys1552, and Lys1546, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone + acetyl-CoA | - |
Homo sapiens | acetyl-histone + CoA | - |
? | |
additional information | acetylation of proteins by the enzyme plays a critical role in the regulation of gene expression | Homo sapiens | ? | - |
? | |
additional information | in absence of acceptor substrate the enzyme performs autoacetylation, identification of 13 autoacetylation sites and mechanism, autoacetylation catalyzed by p300 HAT is about 1000-fold more efficient than p300/CREB-binding protein-associated factor-mediated acetylation of catalytically defective p300 HAT, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
p300 HAT | - |
Homo sapiens |
p300 histone acetyltransferase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00002 | - |
Lys-CoA | inhibition of peptide acetylation | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0001 | - |
autoacetylation IC50: 100 nM, below | Homo sapiens | Lys-CoA |