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Literature summary for 2.3.1.48 extracted from

  • Li, X.; Hu, X.; Patel, B.; Zhou, Z.; Liang, S.; Ybarra, R.; Qiu, Y.; Felsenfeld, G.; Bungert, J.; Huang, S.
    H4R3 methylation facilitates beta-globin transcription by regulating histone acetyltransferase binding and H3 acetylation (2010), Blood, 115, 2028-2037.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
dimethyl-arginine 3-histone H4 dimethyl H4R3 provides a binding surface for PCAF and directly enhances histone H3 and H4 acetylation in vitro Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information knockdown of PRMT1 by RNAi in erythroid progenitor cells prevents histone acetylation, enhancer and promoter interaction, and recruitment of transcription complexes to the active beta-globin promoter. Restoration of PRMT1 expression in PRMT1 knockout cells rescues erythroid differentiation and beta-globin transcription Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone H3 Mus musculus H4R3 methylation, catalyzed by PRMT1, facilitates beta-globin transcription by regulating histone acetyltransferase binding, and histone H3 and H4 acetylation, overview CoA + acetylhistone H3
-
?
acetyl-CoA + histone H4 Mus musculus H4R3 methylation, catalyzed by PRMT1, facilitates beta-globin transcription by regulating histone acetyltransferase binding, and histone H3 and H4 acetylation, overview CoA + acetylhistone H4
-
?
additional information Mus musculus PCAF is present in USF1/PRMT1 complexes ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
PCAF and CBP
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell
-
Mus musculus
-
erythroid cell
-
Mus musculus
-
MEL cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H3 H4R3 methylation, catalyzed by PRMT1, facilitates beta-globin transcription by regulating histone acetyltransferase binding, and histone H3 and H4 acetylation, overview Mus musculus CoA + acetylhistone H3
-
?
acetyl-CoA + histone H3 acetylation of Lys9 and Lys14 by PCAF. PCAF binds to dimethyl-Arg3 at histone H4 tails, dimethyl H4R3 provides a binding surface for PCAF and directly enhances histone H3 and H4 acetylation in vitro Mus musculus CoA + acetylhistone H3
-
?
acetyl-CoA + histone H4 H4R3 methylation, catalyzed by PRMT1, facilitates beta-globin transcription by regulating histone acetyltransferase binding, and histone H3 and H4 acetylation, overview Mus musculus CoA + acetylhistone H4
-
?
acetyl-CoA + histone H4 PCAF binds to dimethyl-Arg3 at histone H4 tails, dimethyl H4R3 provides a binding surface for PCAF and directly enhances histone H3 and H4 acetylation in vitro Mus musculus CoA + acetylhistone H4
-
?
additional information PCAF is present in USF1/PRMT1 complexes Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
Cbp
-
Mus musculus
PCAF
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Mus musculus