Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Asf1 | a histone chaperone that activates the enzyme | Saccharomyces cerevisiae | |
VPS75 | Rtt109's H3-K9 acetylation activity in vitro is enhanced strongly by histone chaperone Vps75, Asf1, and Vps75 are both required for acetylation of Lys9 on H3 in vivo by Rtt109, whereas acetylation of Lys56 on H3 in vivo requires only Asf1 | Saccharomyces cerevisiae |
Protein Variants | Comment | Organism |
---|---|---|
additional information | deletion of either ASF1 or RTT109 in cycling cells ablates H3-K56 acetylation and leads to elevated levels of DNA damage-associated gammaH2A and Rad53 phopshorylation | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Saccharomyces cerevisiae | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | Saccharomyces cerevisiae | Rtt109 is specific for histone H3, acetylation at Lys9 and Lys56. RTT109 has functions in addition to maintaining genome stability | CoA + acetylhistone H3 | - |
? | |
additional information | Saccharomyces cerevisiae | in addition to Asf1, Rtt109 is also functionally linked to Rtt101, Mms1, and Mms22 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native Rtt109, in complex with the histone chaperone Vps75 | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | Rtt109 is specific for histone H3, acetylation at Lys9 and Lys56. RTT109 has functions in addition to maintaining genome stability | Saccharomyces cerevisiae | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H3 | Rtt109 is specific for histone H3, acetylation at Lys9 and Lys56 | Saccharomyces cerevisiae | CoA + acetylhistone H3 | - |
? | |
additional information | in addition to Asf1, Rtt109 is also functionally linked to Rtt101, Mms1, and Mms22 | Saccharomyces cerevisiae | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
histone H3 acetyltransferase | - |
Saccharomyces cerevisiae |
Rtt109 | - |
Saccharomyces cerevisiae |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Saccharomyces cerevisiae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | Rtt109 is important for repairing replication-associated lesions and has functions in addition to maintaining genome stability | Saccharomyces cerevisiae |