Activating Compound | Comment | Organism | Structure |
---|---|---|---|
IKKalpha | after cytokine stimulation, IKKalpha also phosphorylates CBP at Ser1382 and Ser1386, thus enhancing CBP-binding affinity for p65 and CBP HAT activity and, consequently, histone H3 acetylation | Mammalia | |
additional information | CBP is activated by phosphorylation at Ser1382 and Ser1386 | Mammalia | |
p65 | p65-associated HAT activity. TNFalpha-dependent phosphorylation of p65 at either Ser276 or Ser536 increases its interaction with p300 and its subsequent acetylation at Lys310 of the NFkappaB subunit, indicating that p65 phosphorylation regulates subsequent acetylation | Mammalia |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | PPARgamma suppresses eotaxin, an NF-kappaB target, gene expression by direct inhibition of p65-associated HAT activity, for example, by competing with p65 for limited amounts of CBP and/or by recruiting HDAC to the p65-HAT complex | Mammalia |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | recruitment of HATs and HDACs by IkappaBalpha, IKKalpha and IKKgamma | Mammalia | - |
- |
nucleus | - |
Mammalia | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | Mammalia | regulation, detailed overview. Acetylation and deacetylation events, in combination with other post-translational protein modifications, generate an NF-kappaB-signaling code and regulate NF-kappaB-dependent gene transcription in an inducer- and promoter-dependent manner, overview | CoA + acetylhistone H3 | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mammalia | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | IKKalpha phosphorylates and activates CBP at Ser1382 and Ser1386 | Mammalia |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | - |
Mammalia | CoA + acetylhistone H3 | - |
r | |
acetyl-CoA + histone H3 | regulation, detailed overview. Acetylation and deacetylation events, in combination with other post-translational protein modifications, generate an NF-kappaB-signaling code and regulate NF-kappaB-dependent gene transcription in an inducer- and promoter-dependent manner, overview | Mammalia | CoA + acetylhistone H3 | - |
r | |
acetyl-CoA + NF-kB p65 | acetylation of the subunit at Lys310 by p300 or PCAF | Mammalia | CoA + acetyl-NF-kB p65 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cbp | - |
Mammalia |
HAT | - |
Mammalia |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Mammalia |
General Information | Comment | Organism |
---|---|---|
metabolism | histone and non-histone protein acetylation is involved, directly and indirectly, in controlling the duration, strength and specificity of the NF-kappaB-activating signaling pathway at multiple levels. Overview of the NF-kB-signaling pathway. Different signaling pathways can interfere with one another by modulating the availability of HATs or HDACs for a particular transcription complex | Mammalia |
physiological function | histone and non-histone protein acetylation is involved, directly and indirectly, in controlling the duration, strength and specificity of the NF-kappaB-activating signaling pathway at multiple levels. Overview of the NF-kB-signaling pathway, IkappaBalpha and some members of the IKK complex have a nuclear function involving HAT and HDAC recruitment | Mammalia |