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Literature summary for 2.3.1.48 extracted from

  • Vonlaufen, N.; Naguleswaran, A.; Coppens, I.; Sullivan, W.J.
    MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii (2010), J. Biol. Chem., 285, 11154-11161.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Toxoplasma gondii 5737
-

Organism

Organism UniProt Comment Textmining
Toxoplasma gondii
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + H3 peptide
-
 Toxoplasma gondii ?
-
 ?

Synonyms

Synonyms Comment Organism
lysine acetyltransferase
-
 Toxoplasma gondii
TgMYST-B
-
 Toxoplasma gondii

General Information

General Information Comment Organism
malfunction expression of mutant TgMYST-B produces no growth defect and fails to protect against DNA damage Toxoplasma gondii
malfunction overexpression of recombinant, tagged TgMYST-B reduces growth rate in vitro and confers protection from a DNA-alkylating agent. Cells overexpressing TgMYST-B have increased levels of ataxia telangiectasia mutated (ATM) kinase and phosphorylated H2AX and that TgMYST-B localizes to the ATM kinase gene. Pharmacological inhibitors of ATM kinase or KATs reverse the slow growth phenotype seen in parasites overexpressing TgMYST-B Toxoplasma gondii