Activating Compound | Comment | Organism | Structure |
---|---|---|---|
E2F1 | the transcription factor associates with and recruits GCN5 to sites of DNA damage. E2F1 is required for the GCN5-mediated regulation of lung cancer cell growth and for theG1/S transition. Cyclin D1 and cyclin E1 are downstream targets of E2F1. GCN5 is enriched at the E2F1-binding site of the cyclin D1, cyclin E1, or E2F1 promoters | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene GCN5, recombinant expression in HEK-293T cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | gene GCN5 silencing by siRNA | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | Homo sapiens | - |
CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H4 | Homo sapiens | - |
CoA + acetylhistone H4 | - |
? | |
additional information | Homo sapiens | GCN5 directly binds to and increases the histone H3 and H4 acetylation of the cyclin E1, cyclin D1, and E2F1 promoters | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q92830 | gene Gcn5 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
H-358 cell | - |
Homo sapiens | - |
H-460 cell | - |
Homo sapiens | - |
non-small cell lung cancer cell | high GCN5 expression level which correlates with tumor size | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone H3 | - |
Homo sapiens | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H4 | - |
Homo sapiens | CoA + acetylhistone H4 | - |
? | |
additional information | GCN5 directly binds to and increases the histone H3 and H4 acetylation of the cyclin E1, cyclin D1, and E2F1 promoters | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Gcn5 | - |
Homo sapiens |
Kat2A | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | both histone H3 and H4 acetylation were increased upon GCN5 overexpression and decreased upon GCN5 knockdown | Homo sapiens |
physiological function | enzyme GCN5 is a lysine acetyltransferase that generally regulates gene expression, expression of GCN5 promotes cell growth and the G1/S phase transition in multiple lung cancer cell lines. The enzyme potentiates the growth of non-small cell lung cancer via promotion of E2F1, cyclin D1, and cyclin E1 expression. E2F1 associates with and recruits GCN5 to sites of DNA damage. E2F1 is required for the GCN5-mediated regulation of lung cancer cell growth and for theG1/S transition. Cyclin D1 and cyclin E1 are downstream targets of E2F1. GCN5 is enriched at the E2F1-binding site of the cyclin D1, cyclin E1, or E2F1 promoters | Homo sapiens |