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Literature summary for 2.3.1.48 extracted from

  • Chen, L.; Wei, T.; Si, X.; Wang, Q.; Li, Y.; Leng, Y.; Deng, A.; Chen, J.; Wang, G.; Zhu, S.; Kang, J.
    Lysine acetyltransferase GCN5 potentiates the growth of non-small cell lung cancer via promotion of E2F1, cyclin D1, and cyclin E1 expression (2013), J. Biol. Chem., 288, 14510-14521.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
E2F1 the transcription factor associates with and recruits GCN5 to sites of DNA damage. E2F1 is required for the GCN5-mediated regulation of lung cancer cell growth and for theG1/S transition. Cyclin D1 and cyclin E1 are downstream targets of E2F1. GCN5 is enriched at the E2F1-binding site of the cyclin D1, cyclin E1, or E2F1 promoters Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene GCN5, recombinant expression in HEK-293T cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information gene GCN5 silencing by siRNA Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone H3 Homo sapiens
-
CoA + acetylhistone H3
-
?
acetyl-CoA + histone H4 Homo sapiens
-
CoA + acetylhistone H4
-
?
additional information Homo sapiens GCN5 directly binds to and increases the histone H3 and H4 acetylation of the cyclin E1, cyclin D1, and E2F1 promoters ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92830 gene Gcn5
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
H-358 cell
-
Homo sapiens
-
H-460 cell
-
Homo sapiens
-
non-small cell lung cancer cell high GCN5 expression level which correlates with tumor size Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone H3
-
Homo sapiens CoA + acetylhistone H3
-
?
acetyl-CoA + histone H4
-
Homo sapiens CoA + acetylhistone H4
-
?
additional information GCN5 directly binds to and increases the histone H3 and H4 acetylation of the cyclin E1, cyclin D1, and E2F1 promoters Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Gcn5
-
Homo sapiens
Kat2A
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Homo sapiens

General Information

General Information Comment Organism
malfunction both histone H3 and H4 acetylation were increased upon GCN5 overexpression and decreased upon GCN5 knockdown Homo sapiens
physiological function enzyme GCN5 is a lysine acetyltransferase that generally regulates gene expression, expression of GCN5 promotes cell growth and the G1/S phase transition in multiple lung cancer cell lines. The enzyme potentiates the growth of non-small cell lung cancer via promotion of E2F1, cyclin D1, and cyclin E1 expression. E2F1 associates with and recruits GCN5 to sites of DNA damage. E2F1 is required for the GCN5-mediated regulation of lung cancer cell growth and for theG1/S transition. Cyclin D1 and cyclin E1 are downstream targets of E2F1. GCN5 is enriched at the E2F1-binding site of the cyclin D1, cyclin E1, or E2F1 promoters Homo sapiens