Literature summary for 2.3.1.5 extracted from

Sticha, K.R.K.; Bergstrom, C.P.; Wagner, C.R.; Hanna, P.E.
Characterization of hamster recombinant monomorphic and polymorphic arylamine N-acetyltransferases. Bioactivation and mechanism-based inactivation studies with N-hydroxy-2-acetylaminofluorene (1998), Biochem. Pharmacol., 56, 47-59.

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Inhibitors

Inhibitors	Comment	Organism	Structure
N-Hydroxy-2-acetylaminofluorene	mechanism-based inactivator, kinetics	Mesocricetus auratus

Organism

Organism	UniProt	Comment	Textmining
Mesocricetus auratus	-	recombinant NAT1, NAT2	-

Reaction

Reaction	Comment	Organism	Reaction ID
acetyl-CoA + an arylamine = CoA + an N-acetylarylamine	mechanism and inactivation	Mesocricetus auratus	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-hydroxy-2-acetylaminofluorene + 4-aminoazobenzene	much better acetyl donor for NAT1 than for NAT2	Mesocricetus auratus	CoA + ?	-	?

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Release 2023.1 (January 2023)