Cloned (Comment) | Organism |
---|---|
tissue-specific expression analysis of isozyme NAT1 | Mus musculus |
tissue-specific expression analysis of isozyme NAT2 | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of NAT2 knockout mice, phenotype, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 4-aminobiphenyl | Mus musculus | substrate of isozyme NAT2 in liver cytosol | N-acetyl-4-aminobiphenyl + CoA | - |
? | |
acetyl-CoA + an arylamine | Mus musculus | - |
CoA + an N-acetylarylamine | - |
? | |
acetyl-CoA + N-hydroxy-4-aminobiphenyl | Mus musculus | substrate of isozyme NAT2 in liver cytosol | N-acetyl-N-hydroxy-4-aminobiphenyl + CoA | - |
? | |
additional information | Mus musculus | the isozymes catalyze the N-acetylation of aromatic amine and hydrazine drugs and carcinogens, after N-hydroxylation, they also catalyze the metabolic activation of N-hydroxy-arylamines via O-acetylation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P50294 | isozyme NAT1; male mice, isozyme NAT1 | - |
Mus musculus | P50295 | isozyme NAT2; male mice, isozyme NAT2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bladder | - |
Mus musculus | - |
gut | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
additional information | broad tissue distribution of isozyme NAT1, tissue-specific expression analysis of isozyme NAT1 | Mus musculus | - |
additional information | broad tissue distribution of isozyme NAT2, tissue-specific expression analysis of isozymes NAT2 | Mus musculus | - |
pancreas | - |
Mus musculus | - |
prostate gland | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 4-aminobenzoic acid | - |
Mus musculus | CoA + N-acetyl-4-aminobenzoic acid | - |
? | |
acetyl-CoA + 4-aminobiphenyl | substrate of isozyme NAT2 in liver cytosol | Mus musculus | N-acetyl-4-aminobiphenyl + CoA | - |
? | |
acetyl-CoA + 4-aminobiphenyl | substrate of isozyme NAT2 | Mus musculus | N-acetyl-4-aminobiphenyl + CoA | - |
? | |
acetyl-CoA + an arylamine | - |
Mus musculus | CoA + an N-acetylarylamine | - |
? | |
acetyl-CoA + isoniazid | - |
Mus musculus | CoA + an N-acetylisoniazid | - |
? | |
acetyl-CoA + N-hydroxy-4-aminobiphenyl | substrate of isozyme NAT2 in liver cytosol | Mus musculus | N-acetyl-N-hydroxy-4-aminobiphenyl + CoA | - |
? | |
acetyl-CoA + N-hydroxy-4-aminobiphenyl | substrate of isozyme NAT2, O-acetylation activity of NAT2 | Mus musculus | N-hydroxy-O-acetyl-4-aminobiphenyl + CoA | - |
? | |
additional information | the isozymes catalyze the N-acetylation of aromatic amine and hydrazine drugs and carcinogens, after N-hydroxylation, they also catalyze the metabolic activation of N-hydroxy-arylamines via O-acetylation | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NAT | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Mus musculus |