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Literature summary for 2.3.1.5 extracted from

  • Dupret, J.M.; Dairou, J.; Atmane, N.; Rodrigues-Lima, F.
    Inactivation of human arylamine N-acetyltransferase 1 by hydrogen peroxide and peroxynitrite (2005), Methods Enzymol., 400, 215-229.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of His-tagged isozyme NAT1 in Escherichia coli strain BL21(DE3) Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
hydrogen peroxide inactivates isozyme NAT1, in vivo effect, overview Homo sapiens
peroxynitrite inactivates isozyme NAT1, in vivo effect, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + an arylamine Homo sapiens NATs are xenobiotic metabolizing enzymes responsible for the acetylation of many arylamine and heterocyclic amines, they therefore play an important role in the detoxification and activation of numerous drugs and carcinogens, regulation, overview CoA + an N-acetylarylamine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P11245 isozyme NAT2; isozyme NAT2
-
Homo sapiens P18440 isozyme NAT1; isozyme NAT1
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged isozyme NAT1 from Escherichia coli strain BL21(DE3) by nickel affinity chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
intestine isozyme NAT2 mainly Homo sapiens
-
liver isozyme NAT2 mainly Homo sapiens
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MCF-7 cell mammary carcinoma cell line, NAT1 Homo sapiens
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additional information isozyme NAT1 shows a broad tissue distribution Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl acetate + 5-aminosalicylic acid
-
Homo sapiens 4-nitrophenol + 5-acetylaminosalicylic acid
-
?
acetyl-CoA + 4-dimethylaminobenzaldehyde
-
Homo sapiens CoA + 5-acetyl-4-dimethylaminobenzaldehyde
-
?
acetyl-CoA + 5-aminosalicylic acid
-
Homo sapiens CoA + 5-acetylaminosalicylic acid
-
?
acetyl-CoA + an arylamine
-
Homo sapiens CoA + an N-acetylarylamine
-
?
acetyl-CoA + an arylamine NATs are xenobiotic metabolizing enzymes responsible for the acetylation of many arylamine and heterocyclic amines, they therefore play an important role in the detoxification and activation of numerous drugs and carcinogens, regulation, overview Homo sapiens CoA + an N-acetylarylamine
-
?

Synonyms

Synonyms Comment Organism
NAT
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inactivation kinetics of NAT1 by oxidants, overview Homo sapiens