Cloned (Comment) | Organism |
---|---|
NAT1, DNA and amino acid sequence determination and analysis, exon composition, expression analysis, identification of an alternative NAT1 promoter lying 51.5 kb upstream of the NAT1 ORF, all NAT1 P3 mRNAs included 5'-untranslated region internal exons of 61 and 175 nucleotides in addition to the 79 nucleotide 5'-untranslated region exon present in P1 mRNA CAP-dependent amplification of 50-P3 mRNA termini defined an 84 base pair transcription start region in which most start sites are centrally clustered, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | variable expression of isozyme NAT1 due to genetic polymorphism, gene regulation or environmental influences is associated with individual susceptibility to various cancers, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | variable expression of isozyme NAT1 due to genetic polymorphism, gene regulation or environmental influences is associated with individual susceptibility to various cancers, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | the hepatoma-derived cell line expresses a high level of P3 mRNA with the same spliced structure and start site pattern as found in normal tissues | Homo sapiens | - |
kidney | high activity of isozyme NAT1 | Homo sapiens | - |
liver | high activity of isozyme NAT1 | Homo sapiens | - |
lung | high activity of isozyme NAT1 | Homo sapiens | - |
additional information | isozyme NAT1 tissue-specific expression, analysis, overview | Homo sapiens | - |
trachea | high activity of isozyme NAT1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | variable expression of isozyme NAT1 due to genetic polymorphism, gene regulation or environmental influences is associated with individual susceptibility to various cancers, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NAT | - |
Homo sapiens |