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Literature summary for 2.3.1.5 extracted from

  • Kawamura, A.; Westwood, I.; Wakefield, L.; Long, H.; Zhang, N.; Walters, K.; Redfield, C.; Sim, E.
    Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1 (2008), Biochem. Pharmacol., 75, 1550-1560.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli as a His-tagged fusion protein Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
17-hydroxy-beta-estradiol
-
Mus musculus
17-hydroxy-progesterone
-
Mus musculus
4-hydroxy tamoxifen
-
Mus musculus
alpha-zearalenol
-
Mus musculus
androstenedione
-
Mus musculus
beta-zearalenol
-
Mus musculus
bisphenol A
-
Mus musculus
diethylstilbestrol
-
Mus musculus
estrone
-
Mus musculus
genistein
-
Mus musculus
pregnenolone
-
Mus musculus
tamoxifen
-
Mus musculus
testosterone
-
Mus musculus
zearalenone
-
Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
molecular weight of His-tagged fusion protein, determined by SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
using Ni-NTA chromatography Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
28
-
thrombin cleaved fusion protein Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 2-aminofluorene high specific activity Mus musculus CoA + N-acetyl-2-aminofluorene
-
?
acetyl-CoA + 4-aminobenzoic acid high specific activity Mus musculus CoA + N-acetyl-4-aminobenzoic acid
-
?
acetyl-CoA + 4-aminobenzoyl-L-glutamate
-
Mus musculus CoA + N-acetyl-4-aminobenzoyl-L-glutamate
-
?
acetyl-CoA + 4-aminopyridine
-
Mus musculus CoA + N-acetyl-4-aminopyridine
-
?
acetyl-CoA + 4-aminosalicylic acid high specific activity Mus musculus CoA + N-acetyl-4-aminosalicylic acid
-
?
acetyl-CoA + 4-aminoveratrole
-
Mus musculus CoA + N-acetyl-4-aminoveratrole
-
?
acetyl-CoA + 4-bromoaniline
-
Mus musculus CoA + N-acetyl-4-bromoaniline
-
?
acetyl-CoA + 4-butoxyaniline
-
Mus musculus CoA + N-acetyl-4-butoxyaniline
-
?
acetyl-CoA + 4-chloroaniline
-
Mus musculus CoA + N-acetyl-4-chloroaniline
-
?
acetyl-CoA + 4-ethoxyaniline
-
Mus musculus CoA + N-acetyl-4-ethoxyaniline
-
?
acetyl-CoA + 4-hexyloxyaniline
-
Mus musculus CoA + N-acetyl-4-hexyloxyaniline
-
?
acetyl-CoA + 4-iodoaniline
-
Mus musculus CoA + N-acetyl-4-iodoaniline
-
?
acetyl-CoA + 4-methoxyaniline
-
Mus musculus CoA + N-acetyl-4-methoxyaniline
-
?
acetyl-CoA + 4-phenoxyaniline
-
Mus musculus CoA + N-acetyl-4-phenoxyaniline
-
?
acetyl-CoA + 5-aminosalicylic acid high specific activity Mus musculus CoA + N-acetyl-5-aminosalicylic acid
-
?
acetyl-CoA + aniline
-
Mus musculus CoA + N-acetyl-aniline
-
?
acetyl-CoA + hydralazine low specific activity Mus musculus CoA + N-acetyl-hydralazine
-
?
acetyl-CoA + isoniazid low specific activity Mus musculus CoA + N-acetyl-isoniazid
-
?
acetyl-CoA + phenylhydrazine low specific activity Mus musculus CoA + N-acetyl-phenylhydrazine
-
?
acetyl-CoA + procainamide low specific activity Mus musculus CoA + N-acetyl- procainamide
-
?
acetyl-CoA + sulfamethazine low specific activity Mus musculus CoA + N-acetyl-sulfamethazine
-
?
additional information mouse Nat2 is very similar to human NAT1 in substrate specificity Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
N-acetyltransferase type 2
-
Mus musculus
NAT2
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.045
-
-
Mus musculus genistein
0.05
-
-
Mus musculus diethylstilbestrol
0.055
-
-
Mus musculus 17-hydroxy-beta-estradiol
0.057
-
-
Mus musculus tamoxifen
0.065
-
-
Mus musculus 4-OH tamoxifen
0.07
-
-
Mus musculus alpha-zearalenol
0.1
-
value above 0.1 mM Mus musculus pregnenolone
0.22
-
-
Mus musculus zearalenone
0.29
-
-
Mus musculus bisphenol A
0.37
-
-
Mus musculus estrone
0.45
-
-
Mus musculus beta-zearalenol
0.5
-
value above 0.5 mM Mus musculus testosterone
0.5
-
value above 0.5 mM Mus musculus androstenedione
0.5
-
value above 0.5 mM Mus musculus 17-hydroxy-progesterone