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Literature summary for 2.3.1.5 extracted from

  • Lichter, J.; Heckelen, A.; Fischer, K.; Blomeke, B.
    Expression of N-acetyltransferase in monocyte-derived dendritic cells (2008), J. Toxicol. Environ. Health Part A, 71, 960-964.
    View publication on PubMed
Search for more literature for 2.3.1.5

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
monocyte-derived dendritic cell NAT-1 mRNA expression is found in 9 of 10 donors Homo sapiens
-
monocyte-derived dendritic cell NAT-2 mRNA expression weaker thn NAT-1 mRNA expression Homo sapiens
-
peripheral blood mononuclear cell
-
 Homo sapiens
-
peripheral blood mononuclear cell NAT-1 mRNA expression is found in 5 of 7 examined individuals Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.008
-
 enzymatic activity found in peripheral blood mononuclear cell of investigated donors: 8-23.5 nmol/mg/min Homo sapiens
0.0105
-
 enzymatic activity found in HepG2 cells Homo sapiens
0.0234
-
 enzymatic activity found in monocyte-derived dendritic cells of investigated donors: 23.4-26.6 nmol/mg/min Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 4-aminobenzoic acid
-
 Homo sapiens CoA + N-acetyl-4-aminobenzoic acid
-
 ?

Synonyms

Synonyms Comment Organism
arylamine N-acetyltransferase 1
-
 Homo sapiens
arylamine N-acetyltransferase 2
-
 Homo sapiens
NAT1
-
 Homo sapiens
NAT2
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
 Homo sapiens