Literature summary for 2.3.1.5 extracted from

Kim, S.J.; Kang, H.S.; Chang, H.L.; Jung, Y.C.; Sim, H.B.; Lee, K.S.; Ro, J.; Lee, E.S.
Promoter hypomethylation of the N-acetyltransferase 1 gene in breast cancer (2008), Oncol. Rep., 19, 663-668.

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Application

Application	Comment	Organism
medicine	results show that DNA hypomethylation in the NAT1 gene is present in cancerous breast tissues thus indicating that this type of methylation may significantly influence the transcriptional activation of the gene. Therefore, hypomethylation of the NAT1 gene plays a significant role in breast carcinogenesis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	methylation status and the transcriptional activity of NAT1 in breast cancer tissues: methylation of NAT1 gene is identified in 39 of the breast carcinomas (54.2%), 23 normal (76.7%) and 25 benign breast tissue samples (80.6%). Breast cancer tissues show significantly lower methylation rates of the NAT1 promoters than the normal and benign tissues. Cancer tissues show lower methylation density rates than normal and benign breast tissues. Tissues that show aberrant methylation of NAT1 show significantly less mRNA expression compared with the unmethylated cases. 20 cancers from the methylated group show positive staining for the estrogen receptor (ER) (51.3%), while 72.7% from the unmethylated group stain positive	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
arylamine N-acetyltransferase 1	-	Homo sapiens
NAT1	-	Homo sapiens

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Release 2023.1 (January 2023)