Any feedback?
Literature summary for 2.3.1.5 extracted from
- E. coli nitroreductase/CB1954 gene-directed enzyme prodrug therapy: role of arylamine N-acetlytransferase 2 (2008), Cancer Gene Ther., 15, 758-764.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | co-expression of Escherichia coli nitroreductase and arylamine N-acetyltransferase NAT2 in SKOV3 cells decreases the IC50 value of prodrug CB1954, i.e. 5-(aziridin-1-yl)-2,4-dinitrobenzamide, 16fold. The significantly decreased bystander effect may provide a greater clinical response at therapeutic concentrations of CB1954 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
