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Literature summary for 2.3.1.5 extracted from

  • Sim, E.; Abuhammad, A.; Ryan, A.
    Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery (2014), Br. J. Pharmacol., 171, 2705-2725.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.5

Inhibitors

Inhibitors Comment Organism Structure
piperidinol strong inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo isoform NAT1 Homo sapiens
-
gut isoform NAT2 Homo sapiens
-
liver isoform NAT2 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 4-aminosalicylate substrate for isoform NAT1 Homo sapiens CoA + N-acetyl-4-aminosalicylate
-
 ?
acetyl-CoA + hydralazine substrate for isoform NAT2 Homo sapiens CoA + N-acetylhydralazine
-
 ?
acetyl-CoA + N-(4-aminobenzoyl)-L-glutamate substrate for isoform NAT1 Homo sapiens CoA + N-(4-acetylaminobenzoyl)-L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
NAT1 isoform Homo sapiens
NAT2 isoform Homo sapiens

General Information

General Information Comment Organism
physiological function isoform NAT1 is strongly expressed in oestrogen receptor-positive breast cancer and may contribute to folate and acetyl CoA homeostasis Homo sapiens