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Literature summary for 2.3.1.50 extracted from

  • Liu, L.; Martin, R.; Chan, C.
    Palmitate-activated astrocytes via serine palmitoyltransferase increase BACE1 in primary neurons by sphingomyelinases (2013), Neurobiol. Aging, 34, 540-550.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-serine Rattus norvegicus
-
 CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
palmitoyl-CoA + L-serine Rattus norvegicus Sprague Dawley
-
 CoA + 3-dehydro-D-sphinganine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus Sprague Dawley
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte primary rat cortical astrocytes Rattus norvegicus
-
neuron primary Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + L-serine
-
 Rattus norvegicus CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
palmitoyl-CoA + L-serine
-
 Rattus norvegicus Sprague Dawley CoA + 3-dehydro-D-sphinganine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
serine palmitoyltransferase
-
 Rattus norvegicus
SPT
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction inhibiting the enzyme in the astrocytes decreases the levels of both TNFalpha and interleukin-1beta in the conditioned media, which in turn reduced the neural and acidic sphingomyelinase activities and BACE1 level in primary neurons, overview Rattus norvegicus
physiological function serine palmitoyltransferase in the astrocytes increases ceramide levels, which enhances the release of cytokines that mediate the activation of neural and acidic sphingomyelinase (N-SMase and A-SMase) in the neurons, to propagate the deleterious effects of palmitate, i.e. BACE1 upregulation and amyloidogenesis in primary rat neurons, overview Rattus norvegicus