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Literature summary for 2.3.1.51 extracted from

  • Yamada, K.; Okuyama, H.; Endo, Y.; Ikezawa, H.
    Acyltransferase systems involved in phospholipid metabolism in Saccharomyces cerevisiae (1977), Arch. Biochem. Biophys., 183, 281-289.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Saccharomyces cerevisiae 16020
-
microsome
-
Saccharomyces cerevisiae
-
-
mitochondrion the presence of the enzyme in the mitochondrial fraction cannot be explained by the contamination of microsomes in this fraction Saccharomyces cerevisiae 5739
-

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
OC-2
-
Saccharomyces cerevisiae OC-2
-
OC-2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate i.e. lysophosphatidic acid, highly specific for 1-acyl-sn-glycerol 3-phosphate, catalyzes acylation of position 2 hydroxyl-group Saccharomyces cerevisiae CoA + 1,2-diacyl-sn-glycerol 3-phosphate i.e. phosphatidic acid ?
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate effect of substrate concentration Saccharomyces cerevisiae CoA + 1,2-diacyl-sn-glycerol 3-phosphate i.e. phosphatidic acid ?
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate the enzyme utilizes saturated and unsaturated acyl-CoAs at comparable rates Saccharomyces cerevisiae CoA + 1,2-diacyl-sn-glycerol 3-phosphate i.e. phosphatidic acid ?
acyl-CoA + 2-acyl-sn-glycerol 3-phosphate the rate of CoA-liberation is much lower than with 1-acyl-sn-glycerol 3-phosphate Saccharomyces cerevisiae CoA + ?
-
?
additional information very broad specificity for acyl-CoAs, the enzyme does not seem to discriminate strictly the cis and trans configurations or the position of double bond in the fatty acyl moiety Saccharomyces cerevisiae ?
-
?
oleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
Saccharomyces cerevisiae CoA + 1-acyl-2-oleoyl-sn-glycerol 3-phosphate
-
?
palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
Saccharomyces cerevisiae CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 9 broad Saccharomyces cerevisiae