Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | C4B4E7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
germ cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
AGPAT3 | - |
Mus musculus |
LPAAT3 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | isoform LPAAT3 is induced during germ cell maturation. Differentiation of mouse GC-2spd(ts) spermatocytes into spermatides up-regulates isoform LPAAT3 mRNA, increases the amount of polyunsaturated phospholipids, and shifts the specificity for the incorporation of docosahexaenoic acid toward phosphatidylcholine and phosphatidylethanolamine | up |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform LPAAT3 is induced during germ cell maturation. Differentiation of mouse GC-2spd(ts) spermatocytes into spermatides up-regulates isoform LPAAT3 mRNA, increases the amount of polyunsaturated phospholipids, and shifts the specificity for the incorporation of docosahexaenoic acid toward phosphatidylcholine and phosphatidylethanolamine. Stable knockdown of LPAAT3 in GC-2spd(ts) cells significantly decreases microsomal LPAAT3 activity, reduces levels of polyunsaturated phosphatidylethanolamine species, and impairs cell proliferation/survival during geneticin selection | Mus musculus |