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Literature summary for 2.3.1.54 extracted from

  • Leibig, M.; Liebeke, M.; Mader, D.; Lalk, M.; Peschel, A.; Goetz, F.
    Pyruvate formate lyase acts as a formate supplier for metabolic processes during anaerobiosis in Staphylococcus aureus (2011), J. Bacteriol., 193, 952-962.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
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General Information

General Information Comment Organism
physiological function enzyme deletion mutant displays pleiotropic effects. In the mutant, no formate is produced, glucose consumption is delayed, and ethanol production is decreased, whereas acetate and lactate production are unaffected. All metabolic alterations can be restored by addition of formate or complementation of the mutant. In compensation reactions, serine and threonine are consumed better by the mutant than by the wild-type. The mutant displays reduced production of formylated peptides compared to the parental strain. Arginine consumption and arc operon transcription are increased in the mutant. Enzyme plays a significant role in the anaerobic layer of a biofilm Staphylococcus aureus