Activating Compound | Comment | Organism | Structure |
---|---|---|---|
N1,N11-bis(ethyl)-norspermidine | increases SSAT activity, tumor regression analyzed in tumor-bearing transgenic mice expressing SSAT, tumor regression not enhanced by treatment with | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | tumor progression in transgenic mouse lines overexpressing SSAT protein and susceptibility to skin carcinogenesis analyzed | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + spermidine | Mus musculus | - |
CoA + N1-acetylspermidine | - |
? | |
acetyl-CoA + spermine | Mus musculus | - |
CoA + N1-acetylspermine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P48026 | keratin 6 (K6)-spermidine/spermine N1-acetyltransferase (SSAT) transgenic mice, B6D2F2 background | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skin | overexpressed in transgenic mice | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
tumor progression in transgenic mice expressing SSAT depends on elevated activity of ornithine decarboxylase (ODC) and on increased putrescine levels, strategy to modulate polyamine levels through the inhibition of ornithine decarboxylase (ODC) activity or polyamine uptake, but not via increased SSAT expression for cancer chemoprevention | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + spermidine | - |
Mus musculus | CoA + N1-acetylspermidine | - |
? | |
acetyl-CoA + spermine | - |
Mus musculus | CoA + N1-acetylspermine | - |
? | |
acetyl-CoA + spermine | pharmacologic and genetic manipulation of keratin 6 (K6)-spermidine/spermine N1-acetyltransferase (SSAT) transgenic mice subjected to carcinogenesis | Mus musculus | CoA + N1-acetylspermine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
spermidine/spermine N1-acetyltransferase | - |
Mus musculus |
SSAT | - |
Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
activity assay at | Mus musculus |