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Literature summary for 2.3.1.57 extracted from

  • Wang, X.; Feith, D.J.; Welsh, P.; Coleman, C.S.; Lopez, C.; Woster, P.M.; OBrien, T.G.; Pegg, A.E.
    Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis (2007), Carcinogenesis, 28, 2404-2411.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
N1,N11-bis(ethyl)-norspermidine increases SSAT activity, tumor regression analyzed in tumor-bearing transgenic mice expressing SSAT, tumor regression not enhanced by treatment with Mus musculus

Application

Application Comment Organism
medicine tumor progression in transgenic mouse lines overexpressing SSAT protein and susceptibility to skin carcinogenesis analyzed Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + spermidine Mus musculus
-
CoA + N1-acetylspermidine
-
?
acetyl-CoA + spermine Mus musculus
-
CoA + N1-acetylspermine
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P48026 keratin 6 (K6)-spermidine/spermine N1-acetyltransferase (SSAT) transgenic mice, B6D2F2 background
-

Source Tissue

Source Tissue Comment Organism Textmining
skin overexpressed in transgenic mice Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
tumor progression in transgenic mice expressing SSAT depends on elevated activity of ornithine decarboxylase (ODC) and on increased putrescine levels, strategy to modulate polyamine levels through the inhibition of ornithine decarboxylase (ODC) activity or polyamine uptake, but not via increased SSAT expression for cancer chemoprevention Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + spermidine
-
Mus musculus CoA + N1-acetylspermidine
-
?
acetyl-CoA + spermine
-
Mus musculus CoA + N1-acetylspermine
-
?
acetyl-CoA + spermine pharmacologic and genetic manipulation of keratin 6 (K6)-spermidine/spermine N1-acetyltransferase (SSAT) transgenic mice subjected to carcinogenesis Mus musculus CoA + N1-acetylspermine
-
?

Synonyms

Synonyms Comment Organism
spermidine/spermine N1-acetyltransferase
-
Mus musculus
SSAT
-
Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
activity assay at Mus musculus