Application | Comment | Organism |
---|---|---|
medicine | compared with wild-typet mice, the enzyme-deficient mice subjected to endotoxic acute kidney injury have less severe kidney damage as indicated by better preservation of kidney function. Animals treated with MDL72527, an inhibitor of both polyamine oxidase and spermine oxidase, show significant protection against endotoxin-induced acute kidney injury. Increased polyamine catabolism may contribute to kidney damage through generation of by-products of polyamine oxidation | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
SSAT | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | SSAT mRNA expression peaks at threefold 24 h following lipopolysaccharide injection and returns to background levels by 48 h. The activity of SSAT correlates with its mRNA levels | up |
General Information | Comment | Organism |
---|---|---|
physiological function | compared with wild-typet mice, the enzyme-deficient mice subjected to endotoxic acute kidney injury have less severe kidney damage as indicated by better preservation of kidney function. Animals treated with MDL72527, an inhibitor of both polyamine oxidase and spermine oxidase, show significant protection against endotoxin-induced acute kidney injury. Increased polyamine catabolism may contribute to kidney damage through generation of by-products of polyamine oxidation | Mus musculus |