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Literature summary for 2.3.1.6 extracted from
- On the possible mechanism of phenylacetate neurotoxicity: inhibition of choline acetyltransferase by phenylacetyl-CoA (1984), J. Neurochem., 42, 1499-1501.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| phenylacetate | - |
Homo sapiens |  |
| phenylacetyl-CoA | - |
Homo sapiens | |
| phenylbutyrate | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.055 | - |
acetyl-CoA | - |
Homo sapiens | |
| 4.4 | - |
choline | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| placenta | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + choline | - |
Homo sapiens | acetylcholine + CoA | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00031 | - |
phenylacetyl-CoA | - |
Homo sapiens | |
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