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Literature summary for 2.3.1.6 extracted from
- Functional characterization of phosphorylation of 69-kDa human choline acetyltransferase at serine 440 by protein kinase C (2001), J. Biol. Chem., 276, 22244-22250.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of wild-type- and S440A mutant-enzyme in HEK293 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S440A | the wild-type enzyme is distributed predominantly in cytoplasm (88%), with the remainder (12%) bound to cellular membranes, mutation S440A results in localization of the enzyme entirely in cytoplasm | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
| membrane | - |
Rattus norvegicus | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Rattus norvegicus |
| phosphoprotein | serine 440 of the recombinant human 69-kDa protein is the phoshorylation site | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + choline | - |
Homo sapiens | acetylcholine + CoA | - |
? |  |
| acetyl-CoA + choline | - |
Rattus norvegicus | acetylcholine + CoA | - |
? | |
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Release 2023.1 (January 2023)
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