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Literature summary for 2.3.1.6 extracted from
- Stimulation of choline acetyltransferase by C3d, a neural cell adhesion molecule ligand (2009), J. Neurosci. Res., 87, 609-616.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| C3d | a neural cell adhesion molecule ligand, 65-74% activation at 0.001 mM involving the fibroblast growth factor receptor, activation is inhibited by the FGFR inhibitor, SU5402 | Rattus norvegicus |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | promoting ChAT activity and acetylcholine release can lead to treatments for neurodegenerative diseases with cholinergic deficits, such as Alzheimers disease | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + choline | Rattus norvegicus | - |
CoA + O-acetylcholine | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Sprague Dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hippocampus | - |
Rattus norvegicus | - |
| neuron | septal cholinergic | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + choline | - |
Rattus norvegicus | CoA + O-acetylcholine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ChAT | - |
Rattus norvegicus |
| choline acetyltransferase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
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