Literature summary for 2.3.1.61 extracted from

Pettit, F.H.; Hamilton, L.; Munk, P.; Namihira, G.; Eley, M.H.; Willms, C.R.; Reed, L.J.
alpha-Keto acid dehydrogenase complexes. XIX. Subunit structure of the Escherichia coli alpha-ketoglutarate dehydrogenase complex (1973), J. Biol. Chem., 248, 5282-5290.

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Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
1000000	-	sucrose density gradient centrifugation, sedimentation equilibrium	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
succinyl-CoA + dihydrolipoamide	Escherichia coli	-	CoA + S-succinyldihydrolipoamide	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
succinyl-CoA + dihydrolipoamide	-	Escherichia coli	CoA + S-succinyldihydrolipoamide	-	?

Subunits

Subunits	Comment	Organism
polymer	made up of 24 similar structurally identical polypeptide chains	Escherichia coli
polymer	24 * 47000-51000, SDS-PAGE	Escherichia coli
polymer	24 * 39000-42000, sedimentation equilibrium analysis	Escherichia coli

Cofactor

Cofactor	Comment	Organism	Structure
Lipoyl-protein	transsuccinylase core consists of 24 similar polypeptide chains, 12 of these chains contain a covalently bound lipoyl moiety	Escherichia coli

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Release 2023.1 (January 2023)