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Literature summary for 2.3.1.67 extracted from
- 1-Alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase (1992), Methods Enzymol., 209, 396-401.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| AMP-dependent protein kinase | - |
Homo sapiens | |
| bovine serum albumin | optimal concentration of 1-1.5 mg/ml at short incubation periods and 2-2.5 mg bovine serum albumin/ml during longer incubation periods | Homo sapiens |
General Stability
| General Stability | Organism |
|---|---|
| dithiothreitol, 1 mM stabilizes microsomal preparation | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Arachidonoyl-CoA | - |
Homo sapiens |  |
| diisopropylfluorophosphate | - |
Homo sapiens | |
| EGTA | - |
Homo sapiens | |
| MgCl2 | - |
Homo sapiens | |
| MnCl2 | - |
Homo sapiens | |
| N-ethylmaleimide | - |
Homo sapiens | |
| p-bromophenacyl bromide | - |
Homo sapiens | |
| p-chloromercuribenzoate | - |
Homo sapiens | |
| palmitoyl-CoA | - |
Homo sapiens | |
| palmitoyllyso-glycero-3-phosphocholine | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | optimal activity at 0.0002 mM | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine | Homo sapiens | final step in remodelling pathway of PAF biosynthesis | CoA + 2-acetyl-1-alkyl-6-phosphocholine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HL-60 cell | differentiated | Homo sapiens | - |
| spleen | most abundant | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine | final step in remodelling pathway of PAF biosynthesis | Homo sapiens | CoA + 2-acetyl-1-alkyl-6-phosphocholine | - |
? | |
| acetyl-CoA + acyl-lyso-glycero-3-phosphocholine | - |
Homo sapiens | CoA + acetyl-acyl-glycero-3-phosphocholine | - |
? | |
| acetyl-CoA + alk-1-enyl-lyso-glycero-3-phosphoethanolamine | - |
Homo sapiens | CoA + acetyl-alk-1-enyl-glycero-3-phosphoethanolamine | - |
? | |
| acetyl-CoA + alkyl-lyso-glycero-3-phosphoethanolamine | - |
Homo sapiens | CoA + 2-acetyl-alkyl-glycero-3-phosphoethanolamine | - |
? | |
| acetyl-CoA + alkyl-lyso-monomethylethanamine | - |
Homo sapiens | ? | - |
? | |
| acetyl-CoA + alkyl-lyso-N',N'-dimethylethanamine | - |
Homo sapiens | ? | - |
? | |
| acetyl-CoA + alkyl-sn-glycero-3-phosphocholine | alkyl-lyso-sn-glycero-3-phosphocholine is preferred to its saturated counterpart as substrate | Homo sapiens | CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine | - |
? | |
| acetyl-CoA + octadecyl-lyso-sn-glycero-3-phosphocholine | - |
Homo sapiens | CoA + 2-acetyl-1-octadecyl-sn-glycero-3-phosphocholine | - |
? | |
| propionyl-CoA + alkyl-lyso-glycero-phosphocholine | - |
Homo sapiens | CoA + 2-propionyl-1-alkyl-sn-glycero-3-phosphocholine | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.9 | - |
assay at | Homo sapiens |
| 6.9 | - |
optimal pH | Homo sapiens |
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Release 2023.1 (January 2023)
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