Application | Comment | Organism |
---|---|---|
medicine | metabolic role in inflammatory disorders using experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis (MS) | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + lyso-platelet-activating factor | Mus musculus | - |
platelet-activating factor + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus | Q8BYI6 | mouse; female mice, 8 weeks old, induced with experimental allergic encephalomyelitis (EAE), induction phase, acute phase, and chronic phase, C57BL/6 genetic background | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
central nervous system | primary cultured cells of | Mus musculus | - |
microglia | mRNA and protein expressed in | Mus musculus | - |
microglia | mRNA transcript and protein are predominatly expressed in experimental allergic encephalomyelitis (EAE) mice | Mus musculus | - |
spinal cord | experimental allergic encephalomyelitis (EAE) mice, after 12d, 19d, and 34d removed | Mus musculus | - |
spinal cord | enzymatic activity and mRNA transcripts are elevated in experimental allergic encephalomyelitis (EAE) mice | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
transcript level and enzyme activity elevated in spinal cord of experimental allergic encephalomyelitis (EAE) mice, correlation with disease severity, accumulation of platelet-activating factor dependent on the group IVA cytosolic PLA2/LysoPAFAT present in infiltrating macrophages and activated microglia | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + lyso-platelet-activating factor | - |
Mus musculus | platelet-activating factor + CoA | - |
? | |
acetyl-CoA + lyso-platelet-activating factor | metabolic processing of platelet-activating factor (PAF) in naive and experimental allergic encephalomyelitis (EAE) mice | Mus musculus | platelet-activating factor + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acetyl-CoA:lysoPAF acetyltransferase | - |
Mus musculus |
lyso-PAF acetyltransferase | - |
Mus musculus |
lysoPAFAT | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | activities of phospholipase A2 and acetyl-CoA:lyso-PAF acetyltransferase (LysoPAFAT) are elevated in the spinal cord of experimental allergic encephalomyelitis (EAE) mice, an animal model for multiple sclerosis, compared with those of naive mice and correlate with disease severity | Mus musculus |