Application | Comment | Organism |
---|---|---|
medicine | the results increases the understanding of the clinical implications of platelet-activating factor inhibition with regard to HIV infection | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lopinavir-r | remaining activity in human mesangial cells: 76%. By contrast no effect on activity is observed in blood of naiive patients treated with the drug | Homo sapiens | |
tenofovir-DF | remaining activity in human mesangial cells: 32%. By contrast no effect on activity is observed in blood of naiive patients treated with the drug | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA | Homo sapiens | lyso-PAF, lyso-platelet-activating factor | 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA | PAF, platelet-activating factor | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
HMC cell | human mesangial cell line | Homo sapiens | - |
mesangial cell | human mesangial cell line | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
specific activity of 32.4%, 1.7 ng/microl Tenofovir-DF in the cell incubation medium of HMC | Homo sapiens |
additional information | - |
specific activity of 76.2%, 1.9 ng/microl Lopinavir-r in the cell incubation medium of HMC | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA | lyso-PAF, lyso-platelet-activating factor | Homo sapiens | 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA | PAF, platelet-activating factor | ? | |
lyso-platelt activating factor + acetyl-CoA | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lyso-PAF-acetyltransferase | - |
Homo sapiens |
Lyso-PAF-AT | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
activity assay | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
7.4 | - |
activity assay | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |