Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Clofibrate | - |
Rattus norvegicus |
Crystallization (Comment) | Organism |
---|---|
- |
Columba sp. |
General Stability | Organism |
---|---|
retains activity indefinitely when kept frozen, pure enzyme retains activity when kept frozen for long periods of time, inactivation of pure preparations occurs during dialysis | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetylcarnitine | competitive inhibition, inhibitor for the forward reaction | Rattus norvegicus | |
acetylcarnitine | - |
Sus scrofa | |
DL-carnitine | inhibitor for the reverse reaction | Rattus norvegicus | |
iodoacetamide | - |
Rattus norvegicus | |
iodoacetamide | - |
Sus scrofa | |
N-ethylmaleimide | - |
Rattus norvegicus | |
N-ethylmaleimide | - |
Sus scrofa | |
p-hydroxymercuribenzoate | - |
Rattus norvegicus | |
p-hydroxymercuribenzoate | - |
Sus scrofa | |
palmitoyl-CoA | - |
Columba sp. | |
palmitoyl-CoA | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.03 | - |
CoASH | - |
Rattus norvegicus | |
0.037 | - |
CoASH | - |
Columba sp. | |
0.038 | - |
butyryl-CoA | - |
Rattus norvegicus | |
0.12 | - |
L-(-)-carnitine | - |
Columba sp. | |
0.28 | - |
acetylcarnitine | - |
Rattus norvegicus | |
0.72 | - |
DL-carnitine | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Columba sp. | - |
- |
microsome | membrane bound | Rattus norvegicus | - |
- |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25000 | - |
1 * 34000 + 1 * 25000, purified from mitochondrial fraction of liver, rats fed on a diet containing ethyl p-chlorophenoxyisobutyrate, SDS-PAGE | Rattus norvegicus |
34000 | - |
1 * 34000 + 1 * 25000, purified from mitochondrial fraction of liver, rats fed on a diet containing ethyl p-chlorophenoxyisobutyrate, SDS-PAGE | Rattus norvegicus |
55000 | - |
gel filtration | Columba sp. |
56000 | - |
gel filtration | Rattus norvegicus |
75000 | - |
SDS-PAGE | Columba sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + carnitine | Rattus norvegicus | - |
O-acetylcarnitine + CoASH | - |
r | |
acetyl-CoA + carnitine | Sus scrofa | - |
O-acetylcarnitine + CoASH | - |
r | |
acetyl-CoA + carnitine | Columba sp. | - |
O-acetylcarnitine + CoASH | - |
r | |
acyl-CoA + carnitine | Rattus norvegicus | - |
acylcarnitine + CoASH | - |
r | |
acyl-CoA + carnitine | Sus scrofa | - |
acylcarnitine + CoASH | - |
r | |
acyl-CoA + carnitine | Columba sp. | - |
acylcarnitine + CoASH | - |
r | |
acylcarnitine + CoASH | Rattus norvegicus | - |
acyl-CoA + carnitine | - |
r | |
acylcarnitine + CoASH | Sus scrofa | - |
acyl-CoA + carnitine | - |
r | |
acylcarnitine + CoASH | Columba sp. | - |
acyl-CoA + carnitine | - |
r | |
O-acetylcarnitine + CoASH | Rattus norvegicus | - |
acetyl-CoA + carnitine | - |
r | |
O-acetylcarnitine + CoASH | Sus scrofa | - |
acetyl-CoA + carnitine | - |
r | |
O-acetylcarnitine + CoASH | Columba sp. | - |
acetyl-CoA + carnitine | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Columba sp. | - |
- |
- |
Rattus norvegicus | - |
rat | - |
Rattus norvegicus | - |
albino | - |
Sus scrofa | - |
swine | - |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
- |
Columba sp. |
partially | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast muscle | - |
Columba sp. | - |
heart | - |
Rattus norvegicus | - |
heart | - |
Sus scrofa | - |
heart | - |
Columba sp. | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Columba sp. | - |
muscle | - |
Rattus norvegicus | - |
muscle | - |
Columba sp. | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
82.83 | - |
- |
Rattus norvegicus |
85 | - |
- |
Rattus norvegicus |
85 | - |
- |
Columba sp. |
Storage Stability | Organism |
---|---|
0-4°C, loses little activity when stored for months | Rattus norvegicus |
0-4°C, loses little activity when stored for months | Columba sp. |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + carnitine | - |
Rattus norvegicus | O-acetylcarnitine + CoASH | - |
r | |
acetyl-CoA + carnitine | - |
Sus scrofa | O-acetylcarnitine + CoASH | - |
r | |
acetyl-CoA + carnitine | - |
Columba sp. | O-acetylcarnitine + CoASH | - |
r | |
acetyl-CoA + L-(-)carnitine | - |
Rattus norvegicus | O-acetylcarnitine + CoASH | - |
r | |
acetyl-CoA + L-(-)carnitine | - |
Sus scrofa | O-acetylcarnitine + CoASH | - |
r | |
acetyl-CoA + L-(-)carnitine | - |
Columba sp. | O-acetylcarnitine + CoASH | - |
r | |
acyl-CoA + carnitine | - |
Rattus norvegicus | acylcarnitine + CoASH | - |
r | |
acyl-CoA + carnitine | - |
Sus scrofa | acylcarnitine + CoASH | - |
r | |
acyl-CoA + carnitine | - |
Columba sp. | acylcarnitine + CoASH | - |
r | |
acylcarnitine + CoASH | - |
Rattus norvegicus | acyl-CoA + carnitine | - |
r | |
acylcarnitine + CoASH | - |
Sus scrofa | acyl-CoA + carnitine | - |
r | |
acylcarnitine + CoASH | - |
Columba sp. | acyl-CoA + carnitine | - |
r | |
additional information | - |
Sus scrofa | ? | - |
? | |
additional information | - |
Columba sp. | ? | - |
? | |
additional information | palmityl-CoA does not act as a substrate for the liver enzyme | Rattus norvegicus | ? | - |
? | |
O-acetylcarnitine + CoASH | - |
Rattus norvegicus | acetyl-CoA + L-(-)carnitine | - |
r | |
O-acetylcarnitine + CoASH | - |
Sus scrofa | acetyl-CoA + L-(-)carnitine | - |
r | |
O-acetylcarnitine + CoASH | - |
Columba sp. | acetyl-CoA + L-(-)carnitine | - |
r | |
O-acetylcarnitine + CoASH | - |
Rattus norvegicus | acetyl-CoA + carnitine | - |
r | |
O-acetylcarnitine + CoASH | - |
Sus scrofa | acetyl-CoA + carnitine | - |
r | |
O-acetylcarnitine + CoASH | - |
Columba sp. | acetyl-CoA + carnitine | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | 1 * 34000 + 1 * 25000, purified from mitochondrial fraction of liver, rats fed on a diet containing ethyl p-chlorophenoxyisobutyrate, SDS-PAGE | Rattus norvegicus |
monomer | - |
Rattus norvegicus |
monomer | 1 * 75000, SDS-PAGE | Columba sp. |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Rattus norvegicus |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
20 | 40 | - |
Rattus norvegicus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | 50 | enzyme retains total activity when kept at 37°C for 30 min, rapid loss of activity above 37°C, loses half of the activity at 40°C for 30 min, but is completely inactivated when kept at 44°C for 30 min or 50°C for 5 min, 75% loss of activity at 37°C for 8 h, only 15% loss when kept at 25°C for 8 h | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.2 | - |
DL-carnitine | - |
Rattus norvegicus | |
8 | - |
palmityl-CoA | substrate carnitine | Rattus norvegicus | |
18.6 | - |
palmityl-CoA | substrate acetyl-CoA | Rattus norvegicus | |
920 | - |
acetylcarnitine | substrate DL-carnitine | Rattus norvegicus |