Literature summary for 2.3.1.7 extracted from

Seiler, S.E.; Martin, O.J.; Noland, R.C.; Slentz, D.H.; DeBalsi, K.L.; Ilkayeva, O.R.; An, J.; Newgard, C.B.; Koves, T.R.; Muoio, D.M.
Obesity and lipid stress inhibit carnitine acetyltransferase activity (2014), J. Lipid Res., 55, 635-644.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in human skeletal myocytes	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
oleoyl-CoA	-	Cavia porcellus
oleoyl-CoA	-	Rattus norvegicus
palmitoyl-CoA	direct mixed-model inhibitor	Cavia porcellus
palmitoyl-CoA	direct mixed-model inhibitor	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.1	-	L-carnitine	at pH 7.8 and 37°C	Cavia porcellus
0.1	-	L-carnitine	at pH 7.8 and 37°C	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Cavia porcellus	5739	-
mitochondrion	-	Rattus norvegicus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Cavia porcellus	-	-	-
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Cavia porcellus
-	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
myocyte	-	Cavia porcellus	-
myocyte	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + L-carnitine	-	Cavia porcellus	CoA + O-acetylcarnitine	-	r
acetyl-CoA + L-carnitine	-	Rattus norvegicus	CoA + O-acetylcarnitine	-	r
butyryl-CoA + L-carnitine	-	Cavia porcellus	CoA + O-butyrylcarnitine	-	r
butyryl-CoA + L-carnitine	preferred substrate	Rattus norvegicus	CoA + O-butyrylcarnitine	-	r
propionyl-CoA + L-carnitine	-	Rattus norvegicus	CoA + O-propionylcarnitine	-	r
propionyl-CoA + L-carnitine	preferred substrate	Cavia porcellus	CoA + O-propionylcarnitine	-	r

Synonyms

Synonyms	Comment	Organism
carnitine acetyltransferase	-	Cavia porcellus
carnitine acetyltransferase	-	Rattus norvegicus
CRAT	-	Cavia porcellus
CRAT	-	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0306	-	at pH 7.8 and 37°C	Cavia porcellus	palmitoyl-CoA
0.178	-	at pH 7.8 and 37°C	Rattus norvegicus	palmitoyl-CoA

Expression

Organism	Comment	Expression
Cavia porcellus	enzyme specific activity is diminished in muscles from obese and diabetic rodents despite increased protein abundance	down
Rattus norvegicus	enzyme specific activity is diminished in muscles from obese and diabetic rodents despite increased protein abundance	down

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Release 2023.1 (January 2023)