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Literature summary for 2.3.1.76 extracted from

  • Muniz, A.; Villazana-Espinoza, E.T.; Thackeray, B.; Tsin, A.T.
    11-cis-Acyl-CoA:retinol O-acyltransferase activity in the primary culture of chicken Muller cells (2006), Biochemistry, 45, 12265-12273.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.76

Activating Compound

Activating Compound Comment Organism Structure
additional information in presence of palmitoyl-CoA and CRALBP, Muller cell membranes synthesize 11-cis-retinyl ester from 11-cis-retinol at a rate which is 20-fold higher than that of all-trans-retinyl ester, in absence of CRALBP, 11-cis-retinyl ester synthesis is greatly reduced by 7-fold, in absence of palmitoyl-CoA, retinyl ester synthesis is not observed Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
progesterone
-
 Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Gallus gallus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + 11-cis-retinol Gallus gallus esterification of 11-cis-retinol is four times greater than esterification of all-trans-retinol in Muller cells CoA + 11-cis-retinyl palmitate
-
 ?
palmitoyl-CoA + all-trans-retinol Gallus gallus esterification of 11-cis-retinol is four times greater than esterification of all-trans-retinol in Muller cells CoA + all-trans-retinyl palmitate
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme partially by membrane preparation Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
Muller cell primary cell culture Gallus gallus
-
retina
-
 Gallus gallus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Gallus gallus
0.000023
-
 11-cis-retinyl ester synthesis in absence of cellular retinol-binding protein Gallus gallus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + 11-cis-retinol
-
 Gallus gallus CoA + 11-cis-retinyl palmitate
-
 ?
palmitoyl-CoA + 11-cis-retinol esterification of 11-cis-retinol is four times greater than esterification of all-trans-retinol in Muller cells Gallus gallus CoA + 11-cis-retinyl palmitate
-
 ?
palmitoyl-CoA + all-trans-retinol
-
 Gallus gallus CoA + all-trans-retinyl palmitate
-
 ?
palmitoyl-CoA + all-trans-retinol esterification of 11-cis-retinol is four times greater than esterification of all-trans-retinol in Muller cells Gallus gallus CoA + all-trans-retinyl palmitate
-
 ?

Synonyms

Synonyms Comment Organism
11-cis-acyl-CoA:retinol O-acyltransferase
-
 Gallus gallus
11-cis-ARAT
-
 Gallus gallus
More cf. EC 2.3.1.135 Gallus gallus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 asay at room temperature Gallus gallus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Gallus gallus