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Literature summary for 2.3.1.78 extracted from

  • Bame, K.J.; Rome, L.H.
    Acetyl coenzyme A:alpha-glucosaminide N-acetyltransferase. Evidence for a transmembrane acetylation mechanism (1985), J. Biol. Chem., 260, 11293-11299.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
acetyl-CoA
-
Rattus norvegicus
coenzyme A
-
Rattus norvegicus
additional information iodoacetamide and N-ethylmaleimide are not inhibitory Rattus norvegicus
N-acetyl-alpha-D-glucosamine
-
Rattus norvegicus
N-acetyl-beta-D-glucosamine
-
Rattus norvegicus
p-chloromercuribenzoate
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.29 0.3 alpha-D-glucosamine
-
Rattus norvegicus
0.55
-
acetyl-CoA
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome enzyme is acetylated at the cytoplasmic side of the lysosome and the acetyl group is then transferred to the inside where it is used to acetylate heparan sulfate Rattus norvegicus 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + heparan sulfate alpha-D-glucosaminide Rattus norvegicus
-
CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide
-
?
additional information Rattus norvegicus enzyme is acetylated at the cytoplasmic side of the lysosome and the acetyl group is then transferred to the inside where it is used to acetylate heparan sulfate ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
acetyl-CoA + heparan sulfate alpha-D-glucosaminide = CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide di-iso ping-pong mechanism Rattus norvegicus
acetyl-CoA + heparan sulfate alpha-D-glucosaminide = CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide transmembranal reaction mechanism Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + alpha-D-glucosamine
-
Rattus norvegicus CoA + N-acetyl-alpha-D-glucosamine
-
?
acetyl-CoA + heparan sulfate alpha-D-glucosaminide
-
Rattus norvegicus CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide
-
?
acetyl-CoA + heparan sulfate alpha-D-glucosaminide brings about the acetylation of glucosamine groups of heparan sulfate and heparin from which the sulfate has been removed Rattus norvegicus CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide
-
?
additional information enzyme is acetylated at the cytoplasmic side of the lysosome and the acetyl group is then transferred to the inside where it is used to acetylate heparan sulfate Rattus norvegicus ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
transmembrane transfer Rattus norvegicus
6
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
5 5.5 pH 5.0: about 30% of activity maximum, pH 5.5: maximum activity above Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3
-
coenzyme A versus acetyl-CoA Rattus norvegicus
7
-
coenzyme A versus N-acetyl-alpha-D-glucosamine Rattus norvegicus
15
-
N-acetyl-alpha-D-glucosamine versus glusosamine, no detergents added Rattus norvegicus
16.5
-
N-acetyl-alpha-D-glucosamine versus acetyl-CoA, no detergents added Rattus norvegicus