KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0013 | - |
tobramycin | pH 7.6, 25°C | Pseudomonas aeruginosa | |
0.0015 | - |
sisomycin | pH 7.6, 25°C | Pseudomonas aeruginosa | |
0.0026 | - |
kanamycin B | pH 7.6, 25°C | Pseudomonas aeruginosa | |
0.0048 | - |
kanamycin A | pH 7.6, 25°C | Pseudomonas aeruginosa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | Q51405 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + kanamycin A | - |
Pseudomonas aeruginosa | CoA + N3'-acetylkanamycin A | - |
? | |
acetyl-CoA + kanamycin B | - |
Pseudomonas aeruginosa | CoA + N3'-acetylkanamycin B | - |
? | |
acetyl-CoA + neomycin | - |
Pseudomonas aeruginosa | CoA + N3-acetylneomycin | - |
? | |
acetyl-CoA + paromomycin | - |
Pseudomonas aeruginosa | CoA + N3-acetylparamomycin | - |
? | |
acetyl-CoA + ribostamycin | - |
Pseudomonas aeruginosa | CoA + N3-acetylribostamycin | - |
? | |
acetyl-CoA + sisomycin | - |
Pseudomonas aeruginosa | CoA + N3'-acetylsisomycin | - |
? | |
acetyl-CoA + tobramycin | - |
Pseudomonas aeruginosa | CoA + N3'-acetyltobramycin | - |
? | |
additional information | isoform AAC-IIIb demonstrates fast antibiotic turnover rates, high antibiotic affinity. Aminoglycoside binding becomes more enthalpically favored and entropically disfavored when CoASH is complexed to AAC-IIIb. The enzyme catalytically and enthalpically favor those aminoglycosides with amine groups at the 2' carbon and show an increase in affinity of all aminoglycosides when CoASH is present | Pseudomonas aeruginosa | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Aac(3)-IIIb | - |
Pseudomonas aeruginosa |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
10 | - |
neomycin | pH 7.6, 25°C | Pseudomonas aeruginosa | |
24 | - |
ribostamycin | pH 7.6, 25°C | Pseudomonas aeruginosa | |
34 | - |
neomycin E | pH 7.6, 25°C | Pseudomonas aeruginosa | |
46 | - |
sisomycin | pH 7.6, 25°C | Pseudomonas aeruginosa | |
48 | - |
tobramycin | pH 7.6, 25°C | Pseudomonas aeruginosa | |
51 | - |
kanamycin A | pH 7.6, 25°C | Pseudomonas aeruginosa | |
55 | - |
kanamycin B | pH 7.6, 25°C | Pseudomonas aeruginosa |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
10600 | - |
kanamycin A | pH 7.6, 25°C | Pseudomonas aeruginosa | |
21200 | - |
kanamycin B | pH 7.6, 25°C | Pseudomonas aeruginosa | |
30700 | - |
sisomycin | pH 7.6, 25°C | Pseudomonas aeruginosa | |
36900 | - |
tobramycin | pH 7.6, 25°C | Pseudomonas aeruginosa |