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Literature summary for 2.3.1.81 extracted from

  • Norris, A.L.; Nickels, J.; Sokolov, A.P.; Serpersu, E.H.
    Protein dynamics are influenced by the order of ligand binding to an antibiotic resistance enzyme (2014), Biochemistry, 53, 30-38.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0013
-
tobramycin pH 7.6, 25°C Pseudomonas aeruginosa
0.0015
-
sisomycin pH 7.6, 25°C Pseudomonas aeruginosa
0.0026
-
kanamycin B pH 7.6, 25°C Pseudomonas aeruginosa
0.0048
-
kanamycin A pH 7.6, 25°C Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa Q51405
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + kanamycin A
-
Pseudomonas aeruginosa CoA + N3'-acetylkanamycin A
-
?
acetyl-CoA + kanamycin B
-
Pseudomonas aeruginosa CoA + N3'-acetylkanamycin B
-
?
acetyl-CoA + neomycin
-
Pseudomonas aeruginosa CoA + N3-acetylneomycin
-
?
acetyl-CoA + paromomycin
-
Pseudomonas aeruginosa CoA + N3-acetylparamomycin
-
?
acetyl-CoA + ribostamycin
-
Pseudomonas aeruginosa CoA + N3-acetylribostamycin
-
?
acetyl-CoA + sisomycin
-
Pseudomonas aeruginosa CoA + N3'-acetylsisomycin
-
?
acetyl-CoA + tobramycin
-
Pseudomonas aeruginosa CoA + N3'-acetyltobramycin
-
?
additional information isoform AAC-IIIb demonstrates fast antibiotic turnover rates, high antibiotic affinity. Aminoglycoside binding becomes more enthalpically favored and entropically disfavored when CoASH is complexed to AAC-IIIb. The enzyme catalytically and enthalpically favor those aminoglycosides with amine groups at the 2' carbon and show an increase in affinity of all aminoglycosides when CoASH is present Pseudomonas aeruginosa ?
-
?

Synonyms

Synonyms Comment Organism
Aac(3)-IIIb
-
Pseudomonas aeruginosa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
10
-
neomycin pH 7.6, 25°C Pseudomonas aeruginosa
24
-
ribostamycin pH 7.6, 25°C Pseudomonas aeruginosa
34
-
neomycin E pH 7.6, 25°C Pseudomonas aeruginosa
46
-
sisomycin pH 7.6, 25°C Pseudomonas aeruginosa
48
-
tobramycin pH 7.6, 25°C Pseudomonas aeruginosa
51
-
kanamycin A pH 7.6, 25°C Pseudomonas aeruginosa
55
-
kanamycin B pH 7.6, 25°C Pseudomonas aeruginosa

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
10600
-
kanamycin A pH 7.6, 25°C Pseudomonas aeruginosa
21200
-
kanamycin B pH 7.6, 25°C Pseudomonas aeruginosa
30700
-
sisomycin pH 7.6, 25°C Pseudomonas aeruginosa
36900
-
tobramycin pH 7.6, 25°C Pseudomonas aeruginosa