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Literature summary for 2.3.1.82 extracted from

  • Vetting, M.W.; Magnet, S.; Nieves, E.; Roderick, S.L.; Blanchard, J.S.
    A bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones (2004), Chem. Biol., 11, 565-573.
    View publication on PubMed
Search for more literature for 2.3.1.82

Crystallization (Commentary)

Crystallization (Comment) Organism
recombinant enzyme, vapor diffusion under oil, CoA-ribostamycin ternary complex Salmonella enterica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Salmonella enterica confer broad aminoglycoside resistance in strains in which the structural gene is expressed ?
-
 ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica
-
 chromosomally encoded
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information the enzyme catalyzes its own alpha-N-acetylation after posttranslational enzymaric deformylation and removal of the initiator Met Salmonella enterica

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + human histone H3 peptide containing a C-terminal cysteine residue
-
 Salmonella enterica CoA + ?
-
 ?
additional information confer broad aminoglycoside resistance in strains in which the structural gene is expressed Salmonella enterica ?
-
 ?
additional information AAC(6')-Iy catalyzes both acetyl-CoA-dependent self-alpha-N-acetylation and acetylation of eukaryotic histone proteins and the human histone H3 N-terminal peptide Salmonella enterica ?
-
 ?

Synonyms

Synonyms Comment Organism
AAC(6')-Iy
-
 Salmonella enterica