Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | the growth of an amikacin-resistant Klebsiella pneumoniae strain is inhibited when amikacin is supplemented by the addition of Zn2+ or Cu2+ in complex with the ionophore pyrithione | Klebsiella pneumoniae | |
Zn2+ | the growth of an amikacin-resistant Klebsiella pneumoniae strain is inhibited when amikacin is supplemented by the addition of Zn2+ or Cu2+ in complex with the ionophore pyrithione. Addition of 5 microM Zn-pyrithione to cultures containing 16 microg/ml amikacin results in full growth inhibition | Klebsiella pneumoniae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Klebsiella pneumoniae | Q7B8A1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + amikacin | - |
Klebsiella pneumoniae | CoA + 6'-N-acetylamikacin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AAC(6')-Ib | - |
Klebsiella pneumoniae |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0028 | - |
pH not specified in the publication, temperature not specified in the publication | Klebsiella pneumoniae | Cu2+ |