Cloned (Comment) | Organism |
---|---|
- |
Serratia marcescens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | separation of the 3''-adenylyltransferase-aminoglycoside and 6'-acetyltransferase domains of the bifunctional enzyme, and comparison of their activity to that of the full-length enzyme | Serratia marcescens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00055 | - |
amikacin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
0.00177 | - |
netilmicin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
0.00202 | - |
kanamycin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
0.0022 | - |
sisomicin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
0.00387 | - |
netilmicin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
0.0049 | - |
sisomicin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
0.00504 | - |
gentamicin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
0.0079 | - |
tobramycin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
0.0143 | - |
gentamicin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
0.0148 | - |
tobramycin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
0.016 | - |
ribostamycin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
0.016 | - |
kanamycin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
0.023 | - |
neomycin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
0.0321 | - |
neomycin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
0.0693 | - |
ribostamycin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
0.127 | - |
amikacin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
0.147 | - |
acetyl-CoA | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
0.215 | - |
acetyl-CoA | full length enzyme, pH 7.5, 25°C | Serratia marcescens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Serratia marcescens | Q8VQN7 | bifunctional 3''-adenylyltransferase-aminoglycoside and 6'-acetyltransferase | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + amikacin | - |
Serratia marcescens | CoA + 6'-N-acetylamikacin | - |
? | |
acetyl-CoA + gentamicin | - |
Serratia marcescens | CoA + 6'-N-acetylgentamicin | - |
? | |
acetyl-CoA + kanamycin | - |
Serratia marcescens | CoA + 6'-N-acetylkanamycin | - |
? | |
acetyl-CoA + neomycin | - |
Serratia marcescens | CoA + 6'-N-acetylneomycin | - |
? | |
acetyl-CoA + netilmicin | - |
Serratia marcescens | CoA + 6'-N-acetylnetilmicin | - |
? | |
acetyl-CoA + ribostamycin | - |
Serratia marcescens | CoA + 6'-N-acetylribostamycin | - |
? | |
acetyl-CoA + sisomicin | - |
Serratia marcescens | CoA + 6'-N-acetylsisomicin | - |
? | |
acetyl-CoA + tobramycin | - |
Serratia marcescens | CoA + 6'-N-acetyltobramycin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ANT(3'')-Ii/AAC(6')-IId | - |
Serratia marcescens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.11 | - |
gentamicin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
1.62 | - |
acetyl-CoA | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
1.91 | - |
netilmicin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
2.13 | - |
kanamycin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
2.92 | - |
amikacin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
2.93 | - |
sisomicin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
3.21 | - |
netilmicin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
3.33 | - |
gentamicin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
3.73 | - |
tobramycin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
3.81 | - |
kanamycin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
3.84 | - |
tobramycin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
3.88 | - |
ribostamycin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
5.35 | - |
sisomicin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
5.7 | - |
ribostamycin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
7.09 | - |
amikacin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
9.06 | - |
neomycin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
11.1 | - |
neomycin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
12.1 | - |
acetyl-CoA | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
8.4 | - |
acetyl-CoA | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
62.4 | - |
amikacin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
82 | - |
acetyl-CoA | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
82.2 | - |
ribostamycin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
133 | - |
kanamycin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
189 | - |
kanamycin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
220 | - |
gentamicin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
234 | - |
gentamicin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
243 | - |
ribostamycin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
252 | - |
tobramycin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
346 | - |
neomycin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
394 | - |
neomycin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
485 | - |
tobramycin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
829 | - |
netilmicin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
1080 | - |
netilmicin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
1090 | - |
sisomicin | isolated AAC(6') domain, pH 7.5, 25°C | Serratia marcescens | |
1330 | - |
sisomicin | full length enzyme, pH 7.5, 25°C | Serratia marcescens | |
5250 | - |
amikacin | full length enzyme, pH 7.5, 25°C | Serratia marcescens |