Literature summary for 2.3.1.85 extracted from

Rohrbach, K.W.; Han, S.; Gan, J.; O'Tanyi, E.J.; Zhang, H.; Chi, C.L.; Taub, R.; Largent, B.L.; Cheng, D.
Disconnection between the early onset anorectic effects by C75 and hypothalamic fatty acid synthase inhibition in rodents (2005), Eur. J. Pharmacol., 511, 31-41.

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Application

Application	Comment	Organism
medicine	anorectic effect of C75 is independent of its inhibition of enzyme in the hypothalamus	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
C75	i.e. 3-carboxy-4-octyl-2-methylenebutyrolactone, 50% inhibition of enzyme at 0.2 mM	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	Fischer rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hypothalamus	-	Rattus norvegicus	-

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Release 2023.1 (January 2023)