Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(10E,12Z)-octadec-10,12-dienoic acid | more potent inhibitor than (9Z,11E)-octadec-9,11-dienoic acid | Homo sapiens | |
(9Z,11E)-octadec-9,11-dienoic acid | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
colonic cancer cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
LNCaP cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
prostate cancer cell | - |
Homo sapiens | - |
SK-BR-3 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ | - |
Homo sapiens | palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FAS | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | (10E,12Z)-octadec-10,12-dienoic acid downregulates FAS expression in a concnetration-dependent manner, while (9Z,11E)-octadec-9,11-dienoic acid has no effect. (10E,12Z)-octadec-10,12-dienoic acid at 0.05 mM decreases FAS expression in MCF-7 cells by 52%, at 0.1 mM (10E,12Z)-octadec-10,12-dienoic acid, FAS protein is downregulated in MCF-7 (80%), LnCaP (27%), and HT-29 (61%) cells | down |