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Literature summary for 2.3.1.87 extracted from
- In vitro effects of 5-hydroxytryptophan, indoleamines and leptin on arylalkylamine N-acetyltransferase (AA-NAT) activity in pineal organ of the fish, Clarias gariepinus (Burchell, 1822) during different phases of the breeding cycle (2010), Indian J. Exp. Biol., 48, 786-792.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 5-hydroxytryptophan | activates, best at 0.1 mM | Clarias gariepinus |  |
| leptin | increases enzyme activity only in fed fish not in fasted fish, independently of the seasons | Clarias gariepinus | |
| Melatonin | activates, best at 0.1 mM | Clarias gariepinus | |
| N-acetylserotonin | activates, best at 0.1 mM | Clarias gariepinus | |
| serotonin | activates, best at 0.1 mM | Clarias gariepinus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + tryptamine | Clarias gariepinus | - |
CoA + N-acetyltryptamine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clarias gariepinus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pineal gland | from fish in different phases of the annual breeding cycle, and pineal organ culture | Clarias gariepinus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.000027 | - |
enzyme activity on pineal in pineal gland from quiescent phase, pH 6.5, 25°C | Clarias gariepinus |
| 0.000036 | - |
enzyme activity on pineal in pineal gland from progressive phase, pH 6.5, 25°C | Clarias gariepinus |
| 0.000039 | - |
enzyme activity on pineal in pineal gland from breeding phase, pH 6.5, 25°C | Clarias gariepinus |
| 0.000043 | - |
enzyme activity on pineal in pineal gland from regressive phase, pH 6.5, 25°C | Clarias gariepinus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + tryptamine | - |
Clarias gariepinus | CoA + N-acetyltryptamine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AA-NAT | - |
Clarias gariepinus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Clarias gariepinus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
assay at | Clarias gariepinus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| acetyl-CoA | - |
Clarias gariepinus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | arylalkylamine N-acetyltransferase is the rate-limiting enzyme of the melatonin biosynthesis pathway | Clarias gariepinus |
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