Application | Comment | Organism |
---|---|---|
biotechnology | polyketide synthases synthesize the polyketide cores of biologically active compounds, including natural products that have become important pharmaceuticals, like erythromycin | Saccharopolyspora erythraea |
Cloned (Comment) | Organism |
---|---|
the thioesterase domain from deoxyerythronolide B synthase is cloned for expression in Escherichia coli cells | Saccharopolyspora erythraea |
Crystallization (Comment) | Organism |
---|---|
the crystal structure of the thioesterase domain from deoxyerythronolide B synthase is solved to 2.8 A resolution | Saccharopolyspora erythraea |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
33000 | - |
thioesterase domain, 2 * 33000 | Saccharopolyspora erythraea |
66000 | - |
thioesterase domain, homodimer | Saccharopolyspora erythraea |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ | Saccharopolyspora erythraea | - |
6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharopolyspora erythraea | Q03133 | - |
- |
Purification (Comment) | Organism |
---|---|
using a Ni-agarose and a Poros HQ column | Saccharopolyspora erythraea |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
propanoyl-CoA + 6 (2S)-methylmalonyl-CoA + 6 NADPH + 6 H+ | - |
Saccharopolyspora erythraea | 6-deoxyerythronolide B + 7 CoA + 6 CO2 + H2O + 6 NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | thioesterase domain, 2 * 33000 | Saccharopolyspora erythraea |
More | deoxyerythronolide B synthase consists of several modules, formed by acyltransferases, acyl carrier proteins, ketosynthases, ketoreductases, dehydratases, enoylreductases and thioesterases | Saccharopolyspora erythraea |
Synonyms | Comment | Organism |
---|---|---|
DEBS | - |
Saccharopolyspora erythraea |
deoxyerythronolide B synthase | - |
Saccharopolyspora erythraea |
erythromycin polyketide synthase | - |
Saccharopolyspora erythraea |
PKS | - |
Saccharopolyspora erythraea |
polyketide synthase | - |
Saccharopolyspora erythraea |