Literature summary for 2.3.1.97 extracted from

Sogabe, S.; Masubuchi, M.; Sakata, K.; Fukami, T.A.; Morikami, K.; Shiratori, Y.; Ebiike, H.; Kawasaki, K.; Aoki, Y.; Shimma, N.; D'Arcy, A.; Winkler, F.K.; Banner, D.W.; Ohtsuka, T.
Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors (2002), Chem. Biol., 9, 1119-1128.

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Application

Application	Comment	Organism
medicine	target for antiviral and antifungal therapy	Candida albicans

Crystallization (Commentary)

Crystallization (Comment)	Organism
ternary complex formation incubation of protein, 60 mg/ml, with 5fold molar of myristoyl-CoA and inhibitor SC-58272 for a few hours, hanging drop at 4°C, from 0.2 M ammonium acetate, 50 mM HEPES, pH 7.5, 10-12% polyethylene glycol 3350, 2-3 weeks, crystal structure determination by X-ray diffraction analysis	Candida albicans

Protein Variants

Protein Variants	Comment	Organism
additional information	diverse mutants, evaluation of inhibition mechanism of inhibitor SC-58272 and compounds 1-5	Candida albicans

Inhibitors

Inhibitors	Comment	Organism	Structure
benzyl-{3-[2-(2-ethoxymethyl-benzofuran-5-ylmethoxymethyl)-3-methyl-benzofuran-4-yloxy]-propyl}-amine	-	Candida albicans
ethyl 4-[2-hydroxy-3-(isopropylamino)propoxy]-3-methyl-1-benzofuran-2-carboxylate	-	Candida albicans
additional information	inhibition mechanism; inhibitor binding site	Candida albicans
SC-58272	-	Candida albicans
{3-[2-(1H-imidazol-2-yl)-3-methyl-benzofuran-4-yloxy]-propyl}-pyridin-3-ylmethyl-amine	-	Candida albicans
{3-[2-(2,3-difluoro-phenoxymethyl)-3-methyl-benzofuran-4-yloxy]-propyl}-pyridin-3-ylmethyl-amine	-	Candida albicans
{3-[2-(2-ethoxymethyl-benzofuran-5-yloxymethyl)-3-methyl-benzofuran-4-yloxy]-propyl}-pyridin-3-ylmethyl-amine	-	Candida albicans

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
45000	-	1 * 45000, SDS-PAGE	Candida albicans
46000	-	mass spectroscopy	Candida albicans

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
myristoyl-CoA + glycylpeptide	-	Candida albicans	N-myristoylglycylpeptide + CoA	-	?

Subunits

Subunits	Comment	Organism
monomer	1 * 45000, SDS-PAGE	Candida albicans

Synonyms

Synonyms	Comment	Organism
NMT	-	Candida albicans

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
additional information	-	additional information	-	Candida albicans

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Release 2023.1 (January 2023)