Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | predominantly cytosolic isoform NMT2 relocalizes to membranes when cleaved by caspases | Homo sapiens | 5829 | - |
membrane | caspase-mediated cleavage of the predominantly membrane bound isoform NMT1 removes a polybasic domain stretch and leads to a cytosolic relocalization | Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
JURKAT cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
metabolism | both N-myristoyltransferases NMT1 and NMT2 are cleaved during apoptosis. The caspase-3- or -8-mediated cleavage of NMT1 at Asp72 precedes the cleavage of NMT2 by caspase-3 mainly at Asp25. The cleavage of NMTs does not significantly affect their activity in apoptotic cells until the 8 h time point. The cleavage of the predominantly membrane bound NMT1 removes a polybasic domain stretch and leads to a cytosolic relocalization, whereas predominantly cytosolic NMT2 relocalizes to membranes when cleaved after the removal of a negatively charged domain | Homo sapiens |