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Literature summary for 2.3.2.12 extracted from

  • Rakauskaite, R.; Dinman, J.D.
    Mutations of highly conserved bases in the peptidyltransferase center induce compensatory rearrangements in yeast ribosomes (2011), RNA, 17, 855-864.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.12

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli DH5alpha cells Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
additional information three bases in the catalytic core of the peptidyltransferase center - A2819-20 (A2450 and A2451) and U2875 (U2506) - are hyperprotected from 1M7 reagent but not dimethylsulfate modification in U2861A ribosomes Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
valnemulin
-
 Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
ribosome
-
 Saccharomyces cerevisiae 5840
-

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
AcPhe-tRNA + puromycin
-
 Saccharomyces cerevisiae tRNA + AcPhe-puromycin
-
 ?

Synonyms

Synonyms Comment Organism
PTC peptidyltransferase center Saccharomyces cerevisiae