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Literature summary for 2.3.2.12 extracted from
- Genetic characterization of mycobacterial L,D-transpeptidases (2014), Microbiology, 160, 1795-1806.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | mutant DELTAldtC is hypersusceptible to imipenem | Mycolicibacterium smegmatis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Imipenem | - |
Mycobacterium tuberculosis |  |
| Imipenem | - |
Mycolicibacterium smegmatis | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 27600 | - |
x * 27600, LtdA, calculated from amino acid sequence | Mycobacterium tuberculosis |
| 28500 | - |
x * 28500, LtdA, calculated from amino acid sequence | Mycolicibacterium smegmatis |
| 29800 | - |
x * 29800, LtdD, calculated from amino acid sequence | Mycobacterium tuberculosis |
| 38100 | - |
x * 38100, LtdE, calculated from amino acid sequence | Mycolicibacterium smegmatis |
| 40200 | - |
x * 40200, LtdE, calculated from amino acid sequence | Mycobacterium tuberculosis |
| 44000 | - |
x * 44000, LtdB, calculated from amino acid sequence | Mycolicibacterium smegmatis |
| 44900 | - |
x * 44900, LtdB, calculated from amino acid sequence | Mycobacterium tuberculosis |
| 46200 | - |
x * 46200, LtdF, calculated from amino acid sequence | Mycolicibacterium smegmatis |
| 49600 | - |
x * 49600, LtdC, calculated from amino acid sequence | Mycobacterium tuberculosis |
| 49700 | - |
x * 49700, LtdC, calculated from amino acid sequence | Mycolicibacterium smegmatis |
| 49700 | - |
x * 49700, LtdG, calculated from amino acid sequence | Mycolicibacterium smegmatis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peptidyl-tRNA1 + aminoacyl-tRNA2 | Mycolicibacterium smegmatis | - |
tRNA1 + peptidyl(aminoacyl-tRNA2) | - |
? | |
| peptidyl-tRNA1 + aminoacyl-tRNA2 | Mycobacterium tuberculosis | - |
tRNA1 + peptidyl(aminoacyl-tRNA2) | - |
? | |
| peptidyl-tRNA1 + aminoacyl-tRNA2 | Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 | - |
tRNA1 + peptidyl(aminoacyl-tRNA2) | - |
? | |
| peptidyl-tRNA1 + aminoacyl-tRNA2 | Mycobacterium tuberculosis H37Rv | - |
tRNA1 + peptidyl(aminoacyl-tRNA2) | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
| Mycobacterium tuberculosis H37Rv | - |
- |
- |
| Mycolicibacterium smegmatis | - |
- |
- |
| Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peptidyl-tRNA1 + aminoacyl-tRNA2 | - |
Mycolicibacterium smegmatis | tRNA1 + peptidyl(aminoacyl-tRNA2) | - |
? | |
| peptidyl-tRNA1 + aminoacyl-tRNA2 | - |
Mycobacterium tuberculosis | tRNA1 + peptidyl(aminoacyl-tRNA2) | - |
? | |
| peptidyl-tRNA1 + aminoacyl-tRNA2 | - |
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084 | tRNA1 + peptidyl(aminoacyl-tRNA2) | - |
? | |
| peptidyl-tRNA1 + aminoacyl-tRNA2 | - |
Mycobacterium tuberculosis H37Rv | tRNA1 + peptidyl(aminoacyl-tRNA2) | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 27600, LtdA, calculated from amino acid sequence | Mycobacterium tuberculosis |
| ? | x * 28500, LtdA, calculated from amino acid sequence | Mycolicibacterium smegmatis |
| ? | x * 29800, LtdD, calculated from amino acid sequence | Mycobacterium tuberculosis |
| ? | x * 38100, LtdE, calculated from amino acid sequence | Mycolicibacterium smegmatis |
| ? | x * 40200, LtdE, calculated from amino acid sequence | Mycobacterium tuberculosis |
| ? | x * 44000, LtdB, calculated from amino acid sequence | Mycolicibacterium smegmatis |
| ? | x * 44900, LtdB, calculated from amino acid sequence | Mycobacterium tuberculosis |
| ? | x * 46200, LtdF, calculated from amino acid sequence | Mycolicibacterium smegmatis |
| ? | x * 49600, LtdC, calculated from amino acid sequence | Mycobacterium tuberculosis |
| ? | x * 49700, LtdC, calculated from amino acid sequence | Mycolicibacterium smegmatis |
| ? | x * 49700, LtdG, calculated from amino acid sequence | Mycolicibacterium smegmatis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| L,D-transpeptidase | - |
Mycolicibacterium smegmatis |
| L,D-transpeptidase | - |
Mycobacterium tuberculosis |
| LDT | - |
Mycolicibacterium smegmatis |
| LDT | - |
Mycobacterium tuberculosis |
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