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Literature summary for 2.3.2.13 extracted from
- GTP hydrolysis by guinea pig liver transglutaminase (1989), Biochem. Biophys. Res. Commun., 162, 1370-1375.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| GDP | inhibits hydrolysis of GTP | Cavia porcellus |  |
| GDP | inhibits hydrolysis of GTP | Homo sapiens | |
| GTP-gamma-S | inhibition of GTP-hydrolysis | Cavia porcellus | |
| GTP-gamma-S | inhibition of GTP-hydrolysis | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0044 | - |
GTP | GTPase activity | Cavia porcellus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | requirement | Cavia porcellus | |
| Ca2+ | requirement | Homo sapiens | |
| Ca2+ | activation of GTPase activity | Cavia porcellus | |
| Mg2+ | - |
Homo sapiens | |
| Mg2+ | stimulation of GTPase activity, 5 mM | Cavia porcellus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 80000 | - |
1 * 80000, SDS-PAGE | Cavia porcellus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| affinity chromatography on GTP-agarose | Cavia porcellus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Cavia porcellus | - |
| erythrocyte | - |
Homo sapiens | - |
| liver | - |
Cavia porcellus | - |
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | intrinsic GTPase activity | Cavia porcellus | GDP + phosphate | - |
? | |
| protein-bound gamma-glutamine + alkylamine | acyl-transfer reaction | Cavia porcellus | protein N5-alkylglutamine + NH3 | - |
? | |
| protein-bound gamma-glutamine + alkylamine | acyl-transfer reaction | Homo sapiens | protein N5-alkylglutamine + NH3 | - |
? | |
| putrescine + casein | - |
Cavia porcellus | ? | - |
? | |
| putrescine + casein | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | - |
Homo sapiens |
| monomer | 1 * 80000, SDS-PAGE | Cavia porcellus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Cavia porcellus |
| 37 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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