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Literature summary for 2.3.2.2 extracted from

  • Ingbar, D.H.; Hepler, K.; Dowin, R.; Jacobsen, E.; Dunitz, J.M.; Nici, L.; Jamieson, J.D.
    gamma-Glutamyl transpeptidase is a polarized alveolar epithelial membrane protein (1995), Am. J. Physiol., 269, L261-L271.
    View publication on PubMed
Search for more literature for 2.3.2.2

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular extrinsic to plasma membrane Rattus norvegicus
-
-
membrane polarized, outer apical surface alveolar epithelium Rattus norvegicus 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5-L-glutamyl)-peptide + acceptor + H+ Rattus norvegicus
-
 peptide + 5-L-glutamyl amino acid
-
 ?
glutathione + an amino acid Rattus norvegicus ectoenzyme protects the epithelial cells against oxidants by replenishing intracellular glutathione L-cysteinylglycine + a 5-L-glutamyl-amino acid
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 male, Sprague-Dawley
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Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
 Rattus norvegicus
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epithelium alveolar and bronchial, type I and type II cells Rattus norvegicus
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lung alveolar and ciliated bronchial epithelium Rattus norvegicus
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lung fibroblast
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 Rattus norvegicus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 activity during developmental stages in lung epithelial cells type I and II Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5-L-glutamyl)-peptide + acceptor + H+
-
 Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
glutathione + an amino acid ectoenzyme protects the epithelial cells against oxidants by replenishing intracellular glutathione Rattus norvegicus L-cysteinylglycine + a 5-L-glutamyl-amino acid
-
 ?