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Literature summary for 2.3.2.2 extracted from

  • Mehdi, K.; Thierie, J.; Penninckx, M.J.
    gamma-Glutamyl transpeptidase in the yeast Saccharomyces cerevisiae and its role in the vacuolar transport and metabolism of glutathione (2001), Biochem. J., 359, 631-637.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information nitrogen starvation induces enzyme activity Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
18
-
glutathione
-
Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane bound to vascular membrane Saccharomyces cerevisiae 16020
-
vacuole membrane-bound Saccharomyces cerevisiae 5773
-
vacuole regulation of glutathione import into the vacuoles, kinetics Saccharomyces cerevisiae 5773
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione + an amino acid Saccharomyces cerevisiae initial step of glutathione degradation L-cysteinylglycine + a 5-L-glutamyl-amino acid
-
?
glutathione + H2O Saccharomyces cerevisiae
-
L-cysteinylglycine + L-glutamate
-
?
additional information Saccharomyces cerevisiae enzyme activates the yeast cadmium factor 1, responsible for glutathione import into the vacuole ?
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
wild-type and enzyme-deficient strain, nitrogen starvation-induced
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5-L-glutamyl)-peptide + acceptor + H+
-
Saccharomyces cerevisiae peptide + 5-L-glutamyl amino acid
-
?
glutathione + an amino acid initial step of glutathione degradation Saccharomyces cerevisiae L-cysteinylglycine + a 5-L-glutamyl-amino acid
-
?
glutathione + H2O
-
Saccharomyces cerevisiae L-cysteinylglycine + L-glutamate
-
?
glutathione + H2O hydrolase reaction, concurrent to (auto-)transpeptidation Saccharomyces cerevisiae L-cysteinylglycine + L-glutamate
-
?
additional information enzyme activates the yeast cadmium factor 1, responsible for glutathione import into the vacuole Saccharomyces cerevisiae ?
-
?